Petadolex® Educational Handout
What is it?
Butterbur is a perennial shrub with a 2,000 year history of traditional use. In the last twenty-five years, it has been trusted extensively throughout Europe by neurologists and other health professionals. Petadolex®, a patented form of butterbur extracted from the root and standardized to contain a minimum 15% petasin and isopetasin, has been studied for healthy cranial vessel support. It is processed to remove pyrrolizidine alkaloids.*
Uses for butterbur:
- Cranial Vessel Support: In one clinical trial with 60 participants, Petadolex showed the potential to support cranial vessel comfort and was well tolerated. After a twelve-week period, almost eighty percent of participants supplementing with Petadolex indicated a supportive effect. In part, the mechanism for this action may involve a supportive spasmolytic effect on smooth muscle in cranial blood vessels. A second study with 229 individuals indicated similar positive results. In this trial, optimal dosing of Petadolex provided significant support compared to placebo within one month. After three months, over seventy percent of individuals experienced a positive outcome.*
- Maintain Healthy Histamine Release: A petasin-containing butterbur extract has been shown to maintain healthy histamine and cytokine release. In two clinical trials, butterbur maintained healthy nasal histamine release and leukotriene activity, supporting both subjective and objective parameters.*
How much is usually taken?
Pure Encapsulations recommends taking 2-3 capsules per day (providing 15-22.5 mg petasins), in divided doses, with or between meals.
Are there any side effects or precautions?
There have been very rare reports of mild gastrointestinal discomfort with butterbur.
Potential drug interactions:
There are no known drug interations with butterbur supplementation at this time.
Petadolex® is a trademark of Weber & Weber. Manufactured for Pure Encapsulations, Inc by Weber & Weber. Product of Germany.
References:
1.) Lee DK, Carstairs IJ, Haggart K, Jackson CM, Currie GP, Lipworth BJ. Butterbur, a herbal remedy, attenuates adenosine monophosphate induced nasal responsiveness in seasonal allergic rhinitis. Clin Exp Allergy 2003 Jul;33(7):882-6.Ê
2.) Schapowal A; Petasites Study Group. Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. BMJ 2002 Jan 19;324(7330):144-6.
3.) Grossmann M, Schmidramsl H. An extract of Petasites hybridus is effective in the prophylaxis of migraine. Int J Clin Pharmacol Ther 2000 Sep;38(9):430-5.
4.) Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 2003 Jan;43(1):76-8.
5.) Thome OA, Schapowal A, Heinisch IV, Wiesmann UN, Simon HU. Anti-inflammatory activity of an extract of Petasites hybridus in allergic rhinitis. Int Immunopharmacol 2002 Jun;2(7):997-1006.
6.) Thome OA, Wiesmann UN, Schapowal A, Bizer C, Simon HU. Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus. Biochem Pharmacol 2001 Apr 15;61(8):1041-7.
7.) Bickel D, Roder T, Bestmann HJ, Brune K. Identification and characterization of inhibitors of peptido-leukotriene-synthesis from Petasites hybridus. Planta Med 1994 Aug;60(4):318-22.
8.) Brune K, Bickel D, Peskar BA. Gastro-protective effects by extracts of Petasites hybridus: the role of inhibition of peptido-leukotriene synthesis. Planta Med 1993 Dec;59(6):494-6.
For educational purposes only. Consult your physician for any health problems.
*This is a statement of nutritional support. This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
|
