Phase 2 Starch Neutralizer® Educational Handout
What is it?
Phase 2 Starch Neutralizer® (Phase 2®) is a standardized, purified extract of Phaseolus vulgaris bean extract.
What are the uses for Phase 2 Starch Neutralizer®?
- Starch Digestion Support: Several studies have indicated that partially purified kidney bean extract may help mediate the intraduodenal activity of pancreatic alpha-amylase, thereby moderating carbohydrate digestion. Alpha-amylase is a key enzyme that catalyzes the hydrolysis of 1,4-alpha-glycosidic linkages in starch, glycogen, and related polysaccharides. This enzyme is released from both the salivary glands and the pancreas and is involved in the digestion of carbohydrates. When carbohydrates are consumed and reach the small intestine, the pancreas releases alpha-amylase into the duodenum, the uppermost segment of the small intestine, where the enzyme breaks down starch. Two recent double blind, placebo-controlled, crossover trials reported that Phase 2 moderated carbohydrate digestion by an average of 66% for individuals consuming a high carbohydrate, high fat breakfast. When taken with a mixed full meal (carbohydrate, protein and fat), Phase 2 demonstrated the potential to moderate carbohydrate digestion by 28%.*
- Glucose Metabolism Support: A recent study performed at Georgetown University suggests that kidney bean extract moderates starch digestion and maintains healthy postprandial glucose metabolism in animals. Additionally, several human studies performed by the Mayo Clinic also report that partially purified kidney bean extract modulates starch digestion, supports healthy postprandial glucose metabolism and delays gastric emptying. These actions helped to maintain healthy starch metabolism, glucose function and satiety in subjects.*
- Weight Loss Support: Preliminary weight loss trials have also been promising. Results of one trial indicate that a formulation including Phase 2 helped support healthy weight loss in a study involving 60 human volunteers. Phase 2 also promoted healthy weight loss and demonstrated the potential to support healthy triglyceride levels in a study that included 27 participants*
How much is usually taken?
Pure Encapsulations recommends taking 1-3 capsules as the start of a starch-containing meal or snack.
Are there any side effects or precautions?
There are no known side effects associated with Phase 2 Starch Neutralizer®.
Potential drug interactions:
There are no known drug interations with Phase 2® supplementation at this time.
References:
1.) Vinson, JA and Shuta, DM. In Vivo Effectiveness of a Starch Absorption Blocker in a Double-Blind Placebo-Controlled Study with Normal Human Subjects. Department of Chemistry, University of Scranton, Scranton PA. Sept. 2001.
2.) Boivin M, Zinsmeister AR, Go VL, DiMagno EP. Effect of a purified amylase inhibitor on carbohydrate metabolism after a mixed meal in healthy humans. Mayo Clin Proc 1987 Apr;62(4):249-55.
3.) Boivin M, Flourie B, Rizza RA, Go VL, DiMagno EP. Gastrointestinal and metabolic effects of amylase inhibition in diabetics. Gastroenterology 1988 Feb;94(2):387-94.
4.) Layer P, Carlson GL, DiMagno EP. Partially purified white bean amylase inhibitor reduces starch digestion in vitro and inactivates intraduodenal amylase in humans. Gastroenterology 1985 Jun;88(6):1895-902.
5.)Kataoka K, DiMagno EP. Effect of prolonged intraluminal alpha-amylase inhibition on eating, weight, and the small intestine of rats. Nutrition 1999 Feb;15(2):123-9.
6.) Layer P, Rizza RA, Zinsmeister AR, Carlson GL, DiMagno EP. Effect of a purified amylase inhibitor on carbohydrate tolerance in normal subjects and patients with diabetes mellitus. Mayo Clin Proc 1986 Jun;61(6):442-7.
For educational purposes only. Consult your physician for any health problems.
*This is a statement of nutritional support. This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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