CelluPhase: Powerful Protection
for Environmental and Chemical Stress
Cruciferous vegetables of the brassica family have long been
identified as powerful inducers of the liver's natural enzymatic
detoxification system, maintaining healthy cells and tissues.
These effects have been attributed to specific phytochemicals.
Specifically, glucosinolates and their metabolites, including
sulforaphane, are considered to be the most bioactive constituents.
These compounds provide targeted support for phase II liver
enzyme toxin elimination and boost antioxidant activity, in
part by enhancing glutathione synthesis.*
In recent years, glucosinolates have been of particular interest
to the scientific community as an approach for enhancing xenobiotic
metabolism and bolstering the body's defense against environmental
and chemical stress. Experimental and epidemiological studies
present convincing data that cruciferous vegetables support
a variety of cells and tissues.*
Vegetables, like broccoli, cauliflower, brussels sprouts,
and kale are the richest sources of glucosinolates in the
diet. One estimate indicates that about 3-4 servings of broccoli
per week may provide concentrated cellular support. A meta
analysis involving six cohort studies and 74 case-controlled
studies strongly suggests that high consumption of glucosinolate-containing
vegetables maintains healthy colon, prostate, stomach and
lung cells. Additional studies highlight the role of sulforaphane
in supporting DNA integrity and overall liver, skin and breast
cell health.*
Pure Encapsulations CelluPhase
is a broccoli extract and broccoli sprout concentrate combination
for high capacity cellular and detoxification support. One
serving of CelluPhase provides the equivalent of approximately
5 servings of broccoli.
References:
1. Gamet-Payrastre L et al. Sulforaphane, a naturally occurring
isothiocyanate, induces cell cycle arrest and apoptosis in
HT29 human colon cancer cells. Cancer Res 2000 Mar 1;60(5):1426-33.
2. Gao X, Dinkova-Kostova AT, Talalay P. Powerful and prolonged
protection of human retinal pigment epithelial cells, keratinocytes,
and mouse leukemia cells against oxidative damage: the indirect
antioxidant effects of sulforaphane. Proc Natl Acad Sci U
S A. 2001 Dec 18;98(26):15221-6.
3. Jackson SJ, Singletary KW. Sulforaphane inhibits human
MCF-7 mammary cancer cell mitotic progression and tubulin
polymerization. J Nutr. 2004 Sep;134(9):2229-36.
4. Parnaud G et al. Mechanism of sulforaphane-induced cell
cycle arrest and apoptosis in human colon cancer cells. Nutr
Cancer. 2004;48(2):198-206.
5. van Poppel G, Verhoeven DT, Verhagen H, Goldbohm RA. Brassica
vegetables and cancer prevention. Epidemiology and mechanisms.
Adv Exp Med Biol. 1999;472:159-68.
6. Wang L et al. Targeting cell cycle machinery as a molecular
mechanism of sulforaphane in prostate cancer prevention. Int
J Oncol. 2004 Jan;24(1):187-92.
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