SP Ultimate: The Next Generation in Prostate Support
While pomegranate, silymarin, curcumin, green tea and
vitamin D enjoy highly recognized roles in cardiovascular, liver, skin or bone
health, some of the latest advances in prostate research reveal exceptionally
promising support for these ingredients in prostate cell health. Combined with
the time-tested support of saw palmetto, pygeum and phytosterols for prostate
function,
SP Ultimate offers the next level in maintaining a healthy prostate.*
-Supports Urinary and Prostate Function
- Saw palmetto has been used safely for decades to support
healthy prostate and urinary function. Its primary mode of action involves
supporting healthy testosterone metabolism, in part by maintaining healthy
5-alpha-reductase enzyme activity and receptor binding. It may also help
maintain healthy lipoxygenase and cyclooxygenase activity. A meta–analysis
involving 18 randomized controlled trials and almost 3,000 men indicated that
saw palmetto promoted urinary function.*
- Pygeum africanum contains phytosterols, pentacyclic terpenes and ferulic
esters that all play a role in supporting prostate health. Together these
components help maintain healthy prostaglandin and prolactin metabolism in the
prostate. A meta-analysis involving over 1,500 men revealed that pygeum also
promoted urinary function.*
- Beta-sitosterol naturally occurs as part of a phytosterol complex.
Research suggests that it provides support for urinary function in part by
moderating 5-alpha-reductase activity. A meta-analysis involving 4 double blind
trials and over 500 men indicated that it promoted healthy urinary function. A
follow-up study found similar results after 18 months.*
-Promotes Prostate Cell Health
- Numerous studies, including the Health Professionals Follow–Up
Study with over 47,000 participants, suggest that tomato or
lycopene intake is
positively associated with prostate cell health, particularly for intakes of 6
mg or more. Three capsules of SP Ultimate provide 10 mg of lycopene derived from
a natural tomato extract rich in lycopene, carotenoids and phytochemicals.*
- Higher serum
selenium levels have been associated with cell health. In
the body, selenium promotes healthy glutathione peroxidase enzyme activity. A
recent study indicated that daily intake of 200 micrograms yeast-based selenium
supported prostate cell health, particularly for people with lower serum
selenium levels.*
- Vitamin E, or alpha-tocopherol, is a fat-soluble vitamin with critical
antioxidant functions. A large cohort study involving 29,133 men revealed that
alpha-tocopherol supplementation provided healthy cell support for the prostate.
A case-control study using this same population suggests that higher circulating
levels from daily intake of alpha-tocopherol may be particularly important.*
- Research suggests that healthy serum vitamin D levels are positively
associated with prostate cell health, a result of its ability to support healthy
cell cycle function, matrix metalloproteinase (MMP) activity, cell receptor
function and cell signaling.*
- Prostatic secretions contain high concentrations of
zinc suggesting
that it plays an important role in prostate function. Additionally, healthy
plasma concentrations of zinc have been associated with maintaining healthy
prostate cell metabolism.*
- Pomegranate extract is a rich source of antioxidant polyphenols,
including anthocyanidins and ellagic acid. Research indicates that it supports
healthy prostate cell cycle function.*
- Silymarin provides enhanced antioxidant support and promotes healthy
prostate cell cycle function and cell receptor function.*
- Curcumin provides powerful antioxidant support for prostate cell health
and maintains healthy MMP activity.*
- Green tea is rich in polyphenols, particularly the catechin
epigallocatechin gallate (EGCG). A recent study indicates that green tea
polyphenols support healthy cell signaling and MMP activity.*
References
- Wilt TJ, Ishani A,
Stark G, MacDonald R, Lau J, Mulrow C. Saw palmetto extracts for
treatment of benign prostatic hyperplasia: a systematic review. JAMA.
1998 Nov 11;280(18):1604-9.
- Vela Navarrete R,
Garcia Cardoso JV, et al. BPH and inflammation: pharmacological
effects of Permixon on histological and molecular inflammatory
markers. Results of a double blind pilot clinical assay. Eur Urol.
2003 Nov;44(5):549-55.
-
Kucuk O, Sarkar FH,
Sakr W, et al. Phase II randomized clinical trial of lycopene
supplementation before radical prostatectomy. Cancer Epidemiol
Biomarkers Prev. 2001 Aug;10(8):861-8.
-
Giovannucci E, Rimm
EB, Liu Y, et al. A prospective study of tomato products, lycopene,
and prostate cancer risk. J Natl Cancer Inst. 2002 Mar
6;94(5):391-8.
-
Santa Maria Margalef
A, Paciucci Barzanti R, et al. Antimitogenic effect of Pygeum
africanum extracts on human prostatic cancer cell lines and explants
from benign prostatic hyperplasia. Arch Esp Urol. 2003
May;56(4):369-78.
-
Ishani A, MacDonald
R, Nelson D, Rutks I, Wilt TJ. Pygeum africanum for the treatment of
patients with benign prostatic hyperplasia: a systematic review and
quantitative meta-analysis. Am J Med. 2000 Dec 1;109(8):654-64.
-
Berges RR, Windeler
J, Trampisch HJ, Senge T. Randomised, placebo-controlled,
double-blind clinical trial of beta-sitosterol in patients with
benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet.
1995 Jun 17;345(8964):1529-32.
-
Duffield-Lillico AJ,
Dalkin BL, Reid ME, et al. Selenium supplementation, baseline plasma
selenium status and incidence of prostate cancer: an analysis of the
complete treatment period of the Nutritional Prevention of Cancer
Trial. BJU Int. 2003 May;91(7):608-12.
-
Heinonen OP, Albanes
D, Virtamo J, et al. Prostate cancer and supplementation with alpha-tocopherol
and beta-carotene: incidence and mortality in a controlled trial. J
Natl Cancer Inst. 1998 Mar 18;90(6):440-6.
- Tokar EJ, Webber MM.
Cholecalciferol (vitamin D3) inhibits growth and invasion by
up-regulating nuclear receptors and 25-hydroxylase (CYP27A1) in
human prostate cancer cells. Clin Exp Metastasis. 2005;22(3):275-84.
-
Zaichick VY,
Sviridova TV, Zaichick SV Zinc concentration in human prostatic
fluid: normal, chronic prostatitis, adenoma and cancer. Int Urol
Nephrol. 1996;28(5):687-94.
- Malik A, Afaq F,
Sarfaraz S, et al. Pomegranate fruit juice for chemoprevention and
chemotherapy of prostate cancer. Proc Natl Acad Sci U S A. 2005 Oct
11;102(41):14813-8.
-
Zhu W, Zhang JS,
Young CY. Silymarin inhibits function of the androgen receptor by
reducing nuclear localization of the receptor in the human prostate
cancer cell line LNCaP. Carcinogenesis. 2001 Sep;22(9):1399-403.
-
Hong JH, Ahn KS, Bae
E, Jeon SS, Choi HY. The effects of curcumin on the invasiveness of
prostate cancer in vitro and in vivo. Prostate Cancer Prostatic Dis.
2006 Jan 3.
-
Adhami VM, Siddiqui
IA, Ahmad N, Gupta S, Mukhtar H. Oral consumption of green tea
polyphenols inhibits insulin-like growth factor-I-induced signaling
in an autochthonous mouse model of prostate cancer. Cancer Res. 2004 Dec
1;64(23):8715-22
For educational purposes only. Consult your physician for any health problems.
*These statements have not been evaluated by the Food & Drug
Administration. This product is not intended to diagnose, treat, cure or prevent
any disease.
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