The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo
Curcumin has become a focus of interest with regard to its
antitumor effects in prostate cancer; however, the effects of this agent on
invasion and metastasis remain less well understood. Matrix metalloproteinases (MMPs)
are important prerequisite for tumor invasion and metastasis. In this study, we
evaluated the effects of curcumin on prostate cancer cells (DU-145) invasion in
both in vitro and in vivo. We utilized zymography and ELISA in order to
determine the MMP-2 and MMP-9 activity. Matrigel invasion assay was performed to
assess cellular invasion. We developed a xenograft model to examine
tumorigenicity. Curcumin treatment resulted not only in a significant reduction
in the expression of MMP-2 and MMP-9, but also effected the inhibition of
invasive ability in vitro. Curcumin was shown to induce a marked reduction of
tumor volume, MMP-2, and MMP-9 activity in the tumor-bearing site. The
metastatic nodules in vivo were significantly fewer in the curcumin-treated
group than untreated group. Curcumin appears to constitute a potential agent for
the prevention of cancer progression, or at least of the initial phase of
metastasis, in prostate cancer. Hong JH, Ahn KS, Bae E, Jeon SS, Choi HY.
Prostate Cancer Prostatic Dis. 2006 Jan 3.
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