Coenzyme Q10 improves blood pressure and glycaemic control:
a controlled trial in subjects with type 2 diabetes
OBJECTIVE: Our objective was to assess effects
of dietary supplementation with coenzyme Q10 (CoQ) on blood pressure
and glycaemic control in subjects with type 2 diabetes, and to consider
oxidative stress as a potential mechanism for any effects. SUBJECTS
AND DESIGN: Seventy-four subjects with uncomplicated type 2 diabetes
and dyslipidaemia were involved in a randomised double blind placebo-controlled
2x2 factorial intervention. SETTING: The study was performed at the
University of Western Australia, Department of Medicine at Royal Perth
Hospital, Australia. INTERVENTIONS: Subjects were randomly assigned
to receive an oral dose of 100 mg CoQ twice daily (200 mg/day), 200
mg fenofibrate each morning, both or neither for 12 weeks. MAIN OUTCOME
MEASURES: We report an analysis and discussion of the effects of CoQ
on blood pressure, on long-term glycaemic control measured by glycated
haemoglobin (HbA(1c)), and on oxidative stress assessed by measurement
of plasma F2-isoprostanes. RESULTS: Fenofibrate did not alter blood
pressure, HbA(1c), or plasma F2-isoprostanes. There was a 3-fold increase
in plasma CoQ concentration (3.4+/-0.3 micro mol/l, P<0.001) as a
result of CoQ supplementation. The main effect of CoQ was to significantly
decrease systolic (-6.1+/-2.6 mmHg, P=0.021) and diastolic (-2.9+/-1.4
mmHg, P=0.048) blood pressure and HbA(1c) (-0.37+/-0.17%, P=0.032).
Plasma F2-isoprostane concentrations were not altered by CoQ (0.14+/-0.15
nmol/l, P=0.345). CONCLUSIONS: These results show that CoQ supplementation
may improve blood pressure and long-term glycaemic control in subjects
with type 2 diabetes, but these improvements were not associated with
reduced oxidative stress, as assessed by F2-isoprostanes. Hodgson
JM, Watts GF, Playford DA, Burke V, Croft KD. Eur J Clin Nutr.
2002 Nov;56(11):1137-42.
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*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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