Numerous studies have indicated that CoQ10 plays an important role for many aspects of health, including: Cardiovascular Health Research has revealed the important cardiovascular health potential of CoQ10, from supporting hemodynamic properties to healthy lipid metabolism. A meta-analysis involving 8 studies indicated that CoQ10 supplementation promotes ventricular output, or stroke volume. Additional research suggests its ability to maintain healthy ventricular wall thickness. A role in healthy systolic and diastolic function, heart rhythm, endothelial function, and glycemic control has also been indicated. In addition, several randomized double blind, placebo-controlled studies indicate that CoQ10 promotes healthy blood flow by maintaining healthy prostacyclin metabolism. It also promotes healthy lipid metabolism via antioxidant protection. Furthermore, it may help enhance exercise tolerance and moderate muscle fatigue.*

Natural Japanese CoQ10 Brochure Provides detailed information on health benefits, recommendations, pharmacokinetics and our extensive CoQ10 product family. Available online and on our Finished Product Independent Assays CD. You may also call to request your free brochure.

Cognitive and Nerve Health
One multicenter randomized double blind placebo-controlled trial involving 80 participants revealed that CoQ₁₀ promoted cognitive, nerve and motor health, particularly at the higher dosage amounts. Another similar trial indicated that CoQ₁₀ supplementation supported functional capacity.*

Musculoskeletal Health
Two double blind trials, involving individuals ranging in age from 7 to 69 years of age, suggest that healthy plasma CoQ₁₀ levels are important for muscle function. The three-month studies revealed that CoQ₁₀ supplementation promoted muscle bioenergetics and physical performance.*

Cellular Health
A prospective study involving almost 250 people recently revealed that healthy plasma levels of CoQ₁₀ may be related to cell health, particularly for the skin, breast, lung and pancreas. Related studies suggest a relationship between plasma CoQ₁₀ levels and cell membrane antioxidant protection.*

Immune Health
Preliminary but encouraging evidence suggests that CoQ₁₀ supplementation may promote immune function, supporting lymphocyte activity and healthy T4/T8 lymphocyte ratio.*

Oral Health
One double blind study revealed that CoQ₁₀ promotes periodontal health, as indicated by calculus and plaque scores. Another study indicated that CoQ₁₀ supported healthy gums and promoted gingival tissue recovery.*

Cranial Vascular Health
An open label investigation suggests that CoQ₁₀ supports cranial vascular function. The study involved 32 participants supplementing with 150 mg CoQ₁₀ daily. Three months of CoQ₁₀ supplementation revealed statistically significant support for cranial vascular health.*

Skin Health
CoQ₁₀ enhances mitochondrial function, supporting the high-energy demands of skin cell renewal and collagen biosynthesis. It is also one of the only known naturally occurring lipophilic antioxidants present in the skin surface lipids of the epidermis, providing first-line protection from oxidative and environmental assaults. CoQ₁₀ also helps maintain DNA integrity and recycles other powerful antioxidants.*

Men’s Health
Research reveals that CoQ₁₀ may promote sperm cell health. CoQ₁₀ supplementation for 6 months boosted CoQ₁₀ levels in seminal plasma and sperm cells, as well as promoted sperm cell motility.*

CoQ₁₀ Recommendations Overview

References:
1. Burke BE, Neuenschwander R, Olson RD. South Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. Med J. 2001 Nov;94(11):1112-7.
2. Hodgson JM, Watts GF, Playford DA, Burke V, Croft KD. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr. 2002 Nov;56(11):1137-42.
3. Langsjoen P, Langsjoen P, Willis R, Folkers K. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med. 1994;15 Suppl:S265-72.
4. Soja AM, Mortensen SA. Treatment of congestive heart failure with coenzyme Q10 illuminated by meta-analyses of clinical trials. Mol Aspects Med. 1997;18 Suppl:S159-68.
5. Morisco C, Trimarco B, Condorelli M. Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study. Clin Investig. 1993;71(8 Suppl):S134-6.
6. Singh RB, Neki NS, Kartikey K, et al. Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction. Mol Cell Biochem. 2003 Apr;246(1-2):75-82.
7. Kamikawa T, Kobayashi A, Yamashita T, Hayashi H, Yamazaki N. Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. Am J Cardiol. 1985 Aug 1;56(4):247-51.
8. Lonnrot K, Porsti I, Alho H, et al. Control of arterial tone after long-term coenzyme Q10 supplementation in senescent rats. Br J Pharmacol. 1998 Aug;124(7):1500-6.
9. Thibault A, Samid D, Tompkins AC, et al. Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer. Clin Cancer Res. 1996 Mar;2(3):483-91.
10. Shults CW, Oakes D, Kieburtz K, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol. 2002 Oct;59(10):1541-50.
11. Ferrante RJ, Andreassen OA, Dedeoglu A, et al. Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. J Neurosci. 2002 Mar 1;22(5):1592-9.
12. Folkers K, Hanioka T, Xia LJ, McRee JT Jr, Langsjoen P. Coenzyme Q10 increases T4/T8 ratios of lymphocytes in ordinary subjects and relevance to patients having the AIDS related complex. Biochem Biophys Res Commun. 1991 Apr 30;176(2):786-91.
13. Rusciani L, Proietti I, Rusciani A, et al. Low plasma coenzyme Q10 levels as an independent prognostic factor for melanoma progression. J Am Acad Dermatol. 2006 Feb;54(2):234-41.
14. Lockwood K, Moesgaard S, Yamamoto T, Folkers K. Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases. Biochem Biophys Res Commun. 1995 Jul 6;212(1):172-7.
15. Portakal O, Ozkaya O, Erden Inal M, et al. Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem. 2000 Jun;33(4):279-84.
16. Folkers K, Simonsen R. Two successful double-blind trials with coenzyme Q10 (vitamin Q10) on muscular dystrophies and neurogenic atrophies. Biochim Biophys Acta. 1995 May 24;1271(1):281-6.
17. Wilkinson EG, Arnold RM, Folkers K, Hansen I, Kishi H. Bioenergetics in clinical medicine. II. Adjunctive treatment with coenzyme Q in periodontal therapy. Res Commun Chem Pathol Pharmacol. 1975 Sep;12(1):111-23.
18. Wilkinson EG, Arnold RM, Folkers K. Bioenergetics in clinical medicine. VI. adjunctive treatment of periodontal disease with coenzyme Q10. Res Commun Chem Pathol Pharmacol. 1976 Aug;14(4):715-9.
19. Rozen TD, Oshinsky ML, Gebeline CA, et al. Open label trial of coenzyme Q10 as a migraine preventive. Cephalalgia. 2002 Mar;22(2):137-41.
20. Balercia G, Mosca F, Mantero F, et al. Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril. 2004 Jan;81(1):93-8.

For educational purposes only. Consult your physician for any health problems.

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.